A typical day at work turns into a nightmare for Emma Grady when her favorite patient and several colleagues vanish in front of her. Fear turns to chaos as Emma begins the frantic race from Brooklyn to Queens, anxious to discover if her boyfriend is safe. Subways are closed, graves are open, and countless people have inexplicably disappeared. Mayhem erupts as terror grips the residents of New York City. What could make so many vanish in a moment? And not just in New York, but all over the globe? Emma wonders if this is the predicted end of the world and begins a desperate search for answers.